Alloderm is derived from
tissue of postmortem human cadaver donors that have been donated to the US
tissue banks. Alloderm is FDA approved since 1992 and is available for use in
the United States. A thin layer of dermis tissue is taken from a human cadaver
and medically manipulated into a protein only framework, or collagen graft. Any
cells that might cause some sort of rejection are removed during this
Basically Alloderm forms a scaffold onto which your body’s own
collagen can grow, and then eventually the product is completely replaced with
your own tissue. Alloderm acts as a stimulus for collagen to grow in the area
that is treated. There is no risk or rejection or contracting a disease with
the Alloderm graft, as the tissue is put through a process of make it safer,
while retaining all the components your body needs to make it your own tissue.
Image courtesy of
AlloDerm® - Life-Cell
Alloderm grafts have a
long safety record which is made
Life-Cell – and the same company also makes a powder
Cymetra that can be reconstituted and injected.
Before any processing of the skin that takes place with the tissue donors, they
have to undergo meticulous screening by the Tissue Bank. The donor’s medical,
social history and the cause of death are carefully reviewed and documented. The Tissue Banks or a certified laboratory using FDA license extensively test
the blood samples. The donor must be found negative for Hepatitis B and C, HIV
types 1 and 2 antibodies (screening for AIDS) and syphilis.
Allodern sheet Prior to Implantation
SKIN TISSUE GRAFT AFTER PROCESSING. credit: LifeCell
It is important to
understand that human pathogenic viruses, including HIV, require certain type of
human cells to be present and alive in order for the viruses to live and grow
themselves. These viruses essentially are “parasites” of cells and cannot
reproduce without them.
The Alloderm process removes all cells by removing the
components necessary for the survival and spread of these viruses. After the
cell removal the Alloderm grafts are freeze-dried. As a safeguard, Alloderm
grafts undergo microscopic and other diagnostic testing, both before and after
processing, to rule out pathogenic contamination and promote consistent
quality. The tissue essentially becomes your own so the look and
feel is soft, natural and subtle.
Composition: Alloderm implant is
made from human cadaver tissue that has been donated to US tissue banks.
Formulations: Only one
formulation of Alloderm is available - however; Cymetra
is the powder form of Alloderm, which can be reconstituted and injected by
Lasts from 8 months to 2 years.
Test: Not Required
Alloderm: Lip Augmentation with
Alloderm runs anywhere from $1,200 to $3,000
Alloderm requires a surgical procedure, incisions are made in the corners of the
mouth. This procedure is performed under local anesthesia with or without light
sedation or on an out patient basis. The anesthesia that is required for this
procedure is both nerve blocks and local injections. The length of the procedure
is approximately 35 to 45 minutes.
The Alloderm graft, which comes
freeze-dried, is re-hydrated in a sterile solution. The graft is rolled into a
tube to a thickness depending on how much fuller the patient wants the lips to
be. Tiny incisions are made inside each corner of the mouth, and a tunnel is
created under the skin of the lips and the Alloderm is then threaded through. A
single suture is then used to close the incisions and an antibiotic ointment is
applied over these for the next few days until the incision is healed. Oral
antibiotics will also be prescribed to minimize infection risk.