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Injectable Dermal Fillers - Cymetra



                  Image comparing a normal dermis to Alloderm (Cymetra) showing: collagen, elastin, fibroblast, proteoglycans, and blood vessels

                                       Image courtesy of Life-Cell - Permission to use


Cymetra is the micronized injectable form of AlloDerm. It is reconstituted in the physician's office with lidocaine. Like AlloDerm, no allergy testing is required according to the manufacturer, and no known hypersensitivity to the product has been reported.  Cymetra is injected into the dermis to treat deeper wrinkles and acne scars. It is also used in lip augmentation, producing a smooth result.

There have been difficulties with reconstituting Cymetra because of the lumpy and viscous material.  Because of its thickness and viscosity Cymetra requires a very large gauge needle, around 18 - 23 gauge.  The particle size is the limiting factor for needle size. Smaller needles may become clogged.  Cymetra has a unique in-syringe re-hydration system. All components needed come in each package of Cymetra, with only needing saline for reconstitution. 

Cymetra comes packaged as 330 mg dry product in a 5 cc syringe.  Cymetra requires a local or regional anesthesia to be used while administering this product; however some physicians will add lidocaine to the syringe for ease of injection comfort.  




Composition:  Cymetra is composed of micronized (dry powder - Alloderm tissue) used for injection.  This tissue comes from human cadaver tissue which has been donated to the United States Tissue Banks.

Formulation:  330mg. dry product in a 5 cc syringe

Longevity:  3 to 6 months according to the company

Allergy Testing:  Not Required

Cymetra Shelf Life:  Cymetra has a shelf life of 2 years, which will help if the physician wants to store this. 

Cost of Cymetra:  $600 to $1000 per 1.0 cc




Cymetra is derived from human cadavers, like Alloderm.   Because of this; there is no need for an allergy test. Studies have shown that Cymetra tends to last longer than Zyplast collagen. 

Because Cymetra is thicker than Zyplast, it requires a slightly larger needle, which makes the injections a bit more painful.

Patients showing any autoimmune connective tissue disease symptoms should not use this product. Contraindications with AlloDerm or Cymetra include allergy to gentamicin, collagen vascular disease, or infected recipient site. 

Most physicians will not recommend the use of Cymetra in the glabellar region because of the risk of arterial occlusion. If injected periorbitally, these viscous soft tissue fillers can cause overcorrection, local skin necrosis, or retinal artery thrombosis. 



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