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Myobloc / Neurobloc

Myobloc is the anti-wrinkle treatment from Solstice Neurosciences. Myobloc is made by Solstice Neurosciences while BOTOX is from Allergan, Inc.

Myobloc is similar to BOTOX because of the way it is delivered and administered. Both products are reconstituted with saline and use a very fine needle for injection. Both BOTOX and Myobloc address the issues of aging facial skin; however, they are very different in properties since they also differ in serotypes.

Myobloc is derived from Botulinum Toxin Type B while BOTOX is from Botulinum Toxin Type A. Clostridium Botulinum Types B and C cause illness in animals.



                                    Photo courtesy of Myobloc - Solstice Neurosciences

                                         Myobloc - Anti-Wrinkle Treatment



  • Difference of cost to the patient - Myobloc is cheaper in price compared to BOTOX
  • Stored longer than BOTOX


  • Must shorter duration of time compared to BOTOX

  • Mylobloc is slightly more acidic and tends to hurt or burn more when injecting.




                                                   Copyright 2010 ADAM, Inc. - Used with permission

                               One of the injection sites (Glabellar) for Myobloc



Myobloc relieves muscle contraction by blocking acetylcholine- the nerve transmitter that tells the brain to command the muscles to contract upon movement. Injecting Myobloc around the areas in need of treatment - can reduce muscle contraction, which will result in the reduction of fine lines and wrinkles.

It usually lasts up to about 3 months and after that period of time, fine age lines and wrinkles will soon re-appear as the effects of the Myobloc fades. Myobloc does not last as long as BOTOX.



The following are the common side effects of Myobloc:

  • Nausea

  • Burning sensation

  • Headache

  • Minor and temporary discomfort- usually after the treatment




Precautions and Drug Interactions with Myobloc

  • If you are pregnant, planning to become pregnant, or are breastfeeding

  • If you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • If you have allergies to medicines, foods, or other substances

  • If you have nerve problems or disease (amyotrophic lateral sclerosis, motor neuropathy), muscle problems or disease (myasthenia gravis, Lambert-Eaton syndrome), heart problems, bleeding disorders, seizures, or severe weakness or wasting of the muscles at the injection site

  • If you have inflammation, scarring, or other skin disorders at the injection site

  • If you have used other botulinum toxin injections within the past 4 months – such as BOTOX

  • Toxic effects might occur with certain drugs (Gentamycin, Clindamycin) magnesium, neuromuscular blockers, quinidine

  • Anti-coagulants such as Warfin, can increase the risk of bleeding at the injection site.





Myobloc and BOTOX are very similar in their chemical make-up.


The following will show the slight differences between the two:

  • Myobloc is derived from the Type B strain of the bacterium Clostridium Bolutinum

  • Difference in their molecular size Difference in the unit measurement

  • Myobloc tends to produce a shorter term effect than BOTOX

  • Dry mouth is associated with Myobloc use.

  • Myobloc has shown to be more effective in medical conditions like dystonia (a neurological disorder that causes involuntary muscle spasms and twisting of the limbs) and abnormal sweating problems.


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